British Air Force Typhoon FGR4s have joined forces with France's air force in a combined operation targeting an subterranean weapons facility in Syria used by the IS group, according to the British defence ministry.
The location, located using surveillance, was assessed as storing arms and explosives, the release indicated, and was positioned in mountains just above the ancient city of Palmyra in central Syria.
"Our aircraft employed precision-guided Paveway IV munitions to hit a several entry passages down to the facility... preliminary assessments are that the target was engaged successfully," the ministry announced.
There was no sign of any civilian impact in the strike late on Saturday and each participating jet made a safe return, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager tanker plane.
Daesh - referred to as ISIS - established extremist governance over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and commitment to operate in unison with allied nations, to stamp out any resurgence of IS and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary stated.
UK warplanes have performed patrols over Syrian airspace to "forestall any attempted comeback" of Islamic State after its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank all the members of British forces involved in this strike for their expertise and their valour," Healey added. "They were among thousands of British troops deployed over Christmas and New Year. This operation, to take out terrorist threats who pose a risk to our safety, highlights how British military are prepared to act, continuously, keeping Britain secure within its borders and strong abroad."
In December, the United States armed forces conducted what it described as a "massive strike" targeting Daesh sites in the country, after an ambush killed two American soldiers and a local interpreter in Palmyra.
The UN says Islamic State still has between 5,000 and 7,000 fighters in Syria and Iraq.